4-(4-ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(4-ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid
• CAS No.: 135128-60-8
• Molecular Formula: C₂₂H₂₂N₂O₅
• Molecular Weight: 394.427
• Mol file: 135128-60-8.mol

Synonyms:4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid

Chemical Property of 4-(4-ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

4-(4-Ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid

There total 1 articles about 4-(4-ethoxyphenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid (29582-31-8) + edaravone (89-25-8) → 4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid (135128-60-8)

Guidance literature:

In benzene; for 10h; Heating;

DOI:10.1246/bcsj.64.2032

Reference yield: 60.0%

4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid (135128-60-8) → 6-(p-Ethoxyphenyl)-4-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4,5-dihydro-3(2H)-pyridazinone (135128-61-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1246/bcsj.64.2032

Reference yield:

4,5-Dihydro-α-<2-(4-ethoxyphenyl)-2-oxoethyl>-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid (135128-60-8) → 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine (135128-67-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / hydrazine hydrate / ethanol / 5 h / Heating

2: 45 percent / POCl₃ / 0.5 h / Heating

3: 70 percent / hydrazine hydrate / ethanol / 5 h / Heating

4: 49 percent / NaNO₂ / H₂O; acetic acid / 1 h

With hydrazine hydrate; sodium nitrite; trichlorophosphate; In ethanol; water; acetic acid;

DOI:10.1246/bcsj.64.2032

upstream raw materials:

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid

edaravone

Downstream raw materials:

6-(p-Ethoxyphenyl)-4-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4,5-dihydro-3(2H)-pyridazinone

6-(4-Ethoxy-phenyl)-4-(3-methyl-1-phenyl-5-thioxo-4,5-dihydro-1H-pyrazol-4-yl)-2H-pyridazine-3-thione

8-(4-Ethoxy-phenyl)-1-methyl-3-phenyl-3H-4,5-dithia-2,3,6,7-tetraaza-cyclopenta[a]naphthalene

6-(4-Ethoxy-phenyl)-2-methyl-4-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4,5-dihydro-2H-pyridazin-3-one