Technology Process of {3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-phenyl}-methanol
There total 7 articles about {3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-phenyl}-methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxy-benzaldehyde; 1-acetyloxymethyl-3,5-bis(diethoxyphosphorylmethyl)benzene;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
With
sodium hydroxide;
In
water;
DOI:10.1016/S0040-4039(99)01733-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 33 percent / dimethylformamide / 3 h / 100 °C
2: 100 percent / 4 h / 140 °C
3: t-BuOK / tetrahydrofuran / 20 °C
4: aq. NaOH / 2 h / 20 °C
With
sodium hydroxide; potassium tert-butylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2: Arbuzov reaction / 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo015764r
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / aq. HBr / acetic acid / 1 h / 20 °C
2: 33 percent / dimethylformamide / 3 h / 100 °C
3: 100 percent / 4 h / 140 °C
4: t-BuOK / tetrahydrofuran / 20 °C
5: aq. NaOH / 2 h / 20 °C
With
sodium hydroxide; potassium tert-butylate; hydrogen bromide;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
3: Arbuzov reaction / 4: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo015764r
