1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

Base Information

Chemical Name:1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester
CAS No.:1610625-63-2
Molecular Formula:C₁₇H₁₇NO₇
Molecular Weight:347.324
Hs Code.:

Synonyms:1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

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Chemical Property of 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

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Technology Process of 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

There total 10 articles about 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1313405-01-4
1-hydroxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid

: 100-39-0
benzyl bromide

: 1610625-63-2
1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

Guidance literature:: methanol; 1-hydroxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid; With chloro-trimethyl-silane; for 44h; Inert atmosphere;

benzyl bromide; In acetonitrile; for 6h; Reflux;

Reference yield:

: 24207-22-5
2-bromo-3-methoxy-6-methyl-pyridine

: 1610625-63-2
1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium permanganate / water

2.1: triethylamine; dmap / dichloromethane

3.1: aluminum (III) chloride / dichloromethane

4.1: potassium carbonate / acetonitrile / 6 h / Reflux

5.1: sodium hydroxide / water; tetrahydrofuran / 5 h

6.1: trifluoroacetic acid; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

7.1: potassium hydroxide / water / 36 h / 80 °C / Inert atmosphere

8.1: chloro-trimethyl-silane / 44 h / Inert atmosphere

8.2: 6 h / Reflux

With dmap; aluminum (III) chloride; potassium permanganate; chloro-trimethyl-silane; dihydrogen peroxide; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 1610625-63-2
1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; bromine / water

2.1: potassium carbonate / acetonitrile

3.1: potassium permanganate / water

4.1: triethylamine; dmap / dichloromethane

5.1: aluminum (III) chloride / dichloromethane

6.1: potassium carbonate / acetonitrile / 6 h / Reflux

7.1: sodium hydroxide / water; tetrahydrofuran / 5 h

8.1: trifluoroacetic acid; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

9.1: potassium hydroxide / water / 36 h / 80 °C / Inert atmosphere

10.1: chloro-trimethyl-silane / 44 h / Inert atmosphere

10.2: 6 h / Reflux

With dmap; aluminum (III) chloride; potassium permanganate; chloro-trimethyl-silane; dihydrogen peroxide; bromine; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;