ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate
• CAS No.: 126623-86-7
• Molecular Formula: C₁₆H₁₇ClN₂O₇S
• Molecular Weight: 416.839
• Mol file: 126623-86-7.mol

Synonyms:ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate

Chemical Property of ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate

There total 1 articles about ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

sodium ethanolate (141-52-6) + ethyl <3-(p-chlorophenyl)-6-oxo-5H-isothiazolo<5,4-d>isoxazol-5-yl>acetate 4,4-dioxide (126623-80-1) → ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate (126623-86-7)

Guidance literature:

In diethyl ether; ethanol; at 0 ℃; for 1.5h;

DOI:10.1002/hlca.19890720630

Reference yield: 82.0%

methanol (67-56-1) + ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate (126623-86-7) → methyl 3-(p-chlorophenyl)-4<<(methoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate (126623-88-9)

Guidance literature:

With sulfuric acid; for 96h; Heating;

DOI:10.1002/hlca.19890720630

Reference yield:

ethyl 3-(p-chlorophenyl)-4-<<(ethoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate (126623-86-7) → methyl 3-(p-chlorophenyl)-7-hydroxy-5H-isoxazolo<5,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide (126623-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / conc. H₂SO₄ / 96 h / Heating

2: 54 percent / NaOMe / pyridine / 22 h / 20 °C

With sulfuric acid; sodium methylate; In pyridine;

DOI:10.1002/hlca.19890720630

upstream raw materials:

sodium ethanolate

ethyl <3-(p-chlorophenyl)-6-oxo-5H-isothiazolo<5,4-d>isoxazol-5-yl>acetate 4,4-dioxide

Downstream raw materials:

methyl 3-(p-chlorophenyl)-4<<(methoxycarbonyl)methyl>sulfamoyl>isoxazole-5-carboxylate

methyl 3-(p-chlorophenyl)-7-hydroxy-5H-isoxazolo<5,4-e><1,2>thiazine-6-carboxylate 4,4-dioxide