Technology Process of (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetic acid
There total 6 articles about (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: zinc; sodium hydroxide; copper(ll) sulfate pentahydrate / water / 3.5 h / 0 - 20 °C
2: hydrazine hydrate / water / 5 h / 95 °C
3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
4: caesium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
5: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 12 h / 180 °C / Inert atmosphere
6: hydrogenchloride; water / acetic acid / 3 h / 100 °C
With
hydrogenchloride; copper(ll) sulfate pentahydrate; water; potassium carbonate; caesium carbonate; hydrazine hydrate; sodium hydroxide; zinc;
[2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride;
In
water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrazine hydrate / water / 5 h / 95 °C
2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
3: caesium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
4: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 12 h / 180 °C / Inert atmosphere
5: hydrogenchloride; water / acetic acid / 3 h / 100 °C
With
hydrogenchloride; water; potassium carbonate; caesium carbonate; hydrazine hydrate;
[2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride;
In
water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
3: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 12 h / 180 °C / Inert atmosphere
4: hydrogenchloride; water / acetic acid / 3 h / 100 °C
With
hydrogenchloride; water; potassium carbonate; caesium carbonate;
[2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride;
In
acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;