Technology Process of (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)-N-(2,2,2-trifluoroethyl)acetamide
There total 8 articles about (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)-N-(2,2,2-trifluoroethyl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
3: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 12 h / 180 °C / Inert atmosphere
4: hydrogenchloride; water / acetic acid / 3 h / 100 °C
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C
With
hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine;
[2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride;
In
dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: zinc; sodium hydroxide; copper(ll) sulfate pentahydrate / water / 3.5 h / 0 - 20 °C
2: hydrazine hydrate / water / 5 h / 95 °C
3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
4: caesium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
5: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 12 h / 180 °C / Inert atmosphere
6: hydrogenchloride; water / acetic acid / 3 h / 100 °C
7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C
With
hydrogenchloride; copper(ll) sulfate pentahydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; caesium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc;
[2,2]bipyridinyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) chloride;
In
dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
