[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester
• CAS No.: 884306-56-3
• Molecular Formula: C₂₄H₂₂F₃N₃O₅S
• Molecular Weight: 521.517
• Mol file: 884306-56-3.mol

Synonyms:[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester

Chemical Property of [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester

There total 1 articles about [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (3-nitro-5,6,7,8-tetrahydroquinolin-5-yl)carbamate (884306-54-1) + 4-(trifluoro-methoxy)benzene-1-sulfonyl chloride (94108-56-2) → [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester (884306-56-3) + [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-7-yl]-carbamic acid benzyl ester (884306-57-4)

Guidance literature:

benzyl (3-nitro-5,6,7,8-tetrahydroquinolin-7-yl)carbamate; benzyl (3-nitro-5,6,7,8-tetrahydroquinolin-5-yl)carbamate; With tin(ll) chloride; In ethanol; for 14h; Heating / reflux;

4-(trifluoro-methoxy)benzene-1-sulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃;

Reference yield: 56.0%

[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester (884306-56-3) + propionyl chloride (79-03-8) → N-[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-7-yl]-propionamide + N-[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-propionamide (884305-72-0)

Guidance literature:

[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-carbamic acid benzyl ester; [3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-7-yl]-carbamic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

propionyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

benzyl (3-nitro-5,6,7,8-tetrahydroquinolin-5-yl)carbamate

4-(trifluoro-methoxy)benzene-1-sulfonyl chloride

Downstream raw materials:

N-[3-(4-trifluoromethoxy-benzenesulfonylamino)-5,6,7,8-tetrahydro-quinolin-5-yl]-propionamide