2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole

Base Information

• Chemical Name: 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole
• CAS No.: 1228383-97-8
• Molecular Formula: C₁₇H₁₃ClF₃N₃O
• Molecular Weight: 367.758

Synonyms:2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole

Chemical Property of 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole

Chemical Property:

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Technology Process of 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole

There total 1 articles about 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(4-aminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole (1224878-40-3) + chloroacetyl chloride (79-04-9) → 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole (1228383-97-8)

Guidance literature:

With triethylamine; In benzene; Cooling with ice; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2010.02.037

Reference yield: 80.0%

4-phenyl-1-piperazine (92-54-6) + 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole (1228383-97-8) → 1-methyl-2-[4-(2-(4-phenyl-1-piperazinyl)acetyl)-aminophenyl]-5-trifluoromethyl-1H-benzimidazole (1224878-49-2)

Guidance literature:

In ethanol; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2010.02.037

Reference yield: 73.0%

Thiomorpholin (123-90-0) + 2-(4-chloroacetylaminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole (1228383-97-8) → 1-methyl-2-[4-(2-(4-thiomorpholino)acetylamino)phenyl]-5-trifluoromethyl-1H-benzimidazole (1224878-47-0)

Guidance literature:

In ethanol; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2010.02.037

upstream raw materials:

2-(4-aminophenyl)-1-methyl-5-trifluoromethyl-1H-benzimidazole

chloroacetyl chloride

Downstream raw materials:

1-methyl-2-[4-(2-(1-pyrrolidinyl)acetylamino)phenyl]-5-trifluoromethyl-1H-benzimidazole

1-methyl-2-[4-(2-(1-piperidinyl)acetylamino)phenyl]-5-trifluoromethyl-1H-benzimidazole

1-methyl-2-[4-(2-(4-thiomorpholino)acetylamino)phenyl]-5-trifluoromethyl-1H-benzimidazole

1-methyl-2-[4-(2-(4-phenyl-1-piperazinyl)acetyl)-aminophenyl]-5-trifluoromethyl-1H-benzimidazole

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