5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole
• CAS No.: 1613247-67-8
• Molecular Formula: C₂₂H₁₈IN₃O₄S
• Molecular Weight: 547.373
• Mol file: 1613247-67-8.mol

Synonyms:5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole

Chemical Property of 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole

There total 8 articles about 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-N'-(1,3-diphenylbut-3-en-1-ylidene)-3-nitrobenzenesulfonohydrazide (1613246-83-5) → 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole (1613247-67-8)

Guidance literature:

With N-iodo-succinimide; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)ethyl)thiourea; In dichloromethane; at -40 ℃; for 16h; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1021/ol5013982

Reference yield:

3-bromo-2-phenylprop-1-ene (3360-54-1) → 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole (1613247-67-8)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; water / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

3: ethanol / 48 h / 20 °C / Inert atmosphere

4: N-iodo-succinimide; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)ethyl)thiourea / dichloromethane / 16 h / -40 °C / Inert atmosphere

With N-iodo-succinimide; ethanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)ethyl)thiourea; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol5013982

Reference yield:

acetophenone (98-86-2) → 5-(iodomethyl)-1-((3-nitrophenyl)sulfonyl)-3,5-diphenyl-4,5-dihydro-1H-pyrazole (1613247-67-8)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: N-Bromosuccinimide; toluene-4-sulfonic acid / 4 h / 100 °C / Inert atmosphere

3: tetrahydrofuran; water / Inert atmosphere

4: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

5: ethanol / 48 h / 20 °C / Inert atmosphere

6: N-iodo-succinimide; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)ethyl)thiourea / dichloromethane / 16 h / -40 °C / Inert atmosphere

With N-Bromosuccinimide; N-iodo-succinimide; ethanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)ethyl)thiourea; potassium tert-butylate; Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol5013982

upstream raw materials:

(E)-N'-(1,3-diphenylbut-3-en-1-ylidene)-3-nitrobenzenesulfonohydrazide

3-bromo-2-phenylprop-1-ene

acetophenone

(±)-1,3-diphenylbut-3-en-1-ol