{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Base Information

Chemical Name:{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate
CAS No.:1350636-92-8
Molecular Formula:C₁₅H₁₆F₃NO₃S
Molecular Weight:347.358
Hs Code.:

Synonyms:{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Suppliers and Price of {(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of {(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of {(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

There total 9 articles about {(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-91-9
thiobenzoic acid

: 2,2,2-trifluoro-N-(7-oxa-bicyclo[4.1.0]hept-3-yl)-acetamide

: 1350636-92-8
{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Guidance literature:: tetrabutyl-ammonium chloride; In toluene; at 30 - 45 ℃; Inert atmosphere;

Reference yield:

: cyclohex-3-ene-1(R)-carboxylic acid (S)-(-)-α-methylbenzylamine salt

: 1350636-92-8
{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water; tert-butyl methyl ether / 20 - 25 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 95 °C / Reflux

2.2: 0.67 h / 80 - 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 - 25 °C

4.1: triethylamine / dichloromethane / 0.17 h / 20 °C

4.2: 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / chlorobenzene / 3 h / 20 - 42 °C

6.1: tetrabutyl-ammonium chloride / chloroform / 30 - 45 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrabutyl-ammonium chloride; In 1,4-dioxane; dichloromethane; tert-butyl methyl ether; chloroform; water; chlorobenzene; toluene; 2.1: Curtius Rearrangement;

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 1350636-92-8
{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 95 °C / Reflux

1.2: 0.67 h / 80 - 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 - 25 °C

3.1: triethylamine / dichloromethane / 0.17 h / 20 °C

3.2: 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / chlorobenzene / 3 h / 20 - 42 °C

5.1: tetrabutyl-ammonium chloride / chloroform / 30 - 45 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrabutyl-ammonium chloride; In 1,4-dioxane; dichloromethane; chloroform; chlorobenzene; toluene; 1.1: Curtius Rearrangement;