3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion

Base Information

• Chemical Name: 3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion
• CAS No.: 75863-04-6
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.398
• Mol file: 75863-04-6.mol

Synonyms:3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion

Chemical Property of 3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion

There total 41 articles about 3-Methoxy-6,7:8,9-diseco-1,3,5⁽¹⁰⁾,7-oestratetraen-11,17-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone (80868-73-1) → 3-Methoxy-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-11,17-dion (75863-04-6)

Guidance literature:

With sulfuric acid; In methanol; for 24h; Ambient temperature;

DOI:10.1002/jlac.198219821109

Reference yield:

4-methoxysalicylaldehyde (52289-54-0) → rac-3-Methoxy-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-9,17-dion (75863-04-6,75917-50-9,80924-45-4,80952-08-5,84680-71-7,84680-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF; 2) ether, 12 h at room temp.

2: 75 percent / Mn(IV) oxide / petroleum ether / 2 h

With manganese(IV) oxide; magnesium; In Petroleum ether;

DOI:10.1002/jlac.198119811220

Reference yield:

4-bromo-3-methylanisole (27060-75-9) → rac-3-Methoxy-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-9,17-dion (75863-04-6,75917-50-9,80924-45-4,80952-08-5,84680-71-7,84680-72-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, 1 h at 50 deg C; 2) THF, -40 deg C to -20 deg C in 2 h

2: 1) Mg / 1) THF; 2) ether, 12 h at room temp.

3: 75 percent / Mn(IV) oxide / petroleum ether / 2 h

With manganese(IV) oxide; magnesium; In Petroleum ether;

DOI:10.1002/jlac.198119811220

upstream raw materials:

2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)prop-2-en-1-on

(2ω,3S)-2-Methyl-3-vinyl-1-cyclopentanon

(2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

(RS)-2-Vinyl-1,1-cyclopropandicarbonsaeure

Downstream raw materials:

3-O-methyl-17β-oestradiol

3-methoxy-17-hydroxyestra-2,5⁽¹⁰⁾-diene

estrone 3-methyl ether

3-methyl ether of Δ⁹⁽¹¹⁾-dehydroestrone