28783-49-5

Basic information

• Product Name: N-[2-(2-Thienyl)ethyl]forMaMide
• Synonyms: N-[2-(2-Thienyl)ethyl]forMaMide;N-(2-thiophen-2-ylethyl)formamide
• CAS NO: 28783-49-5
• Molecular Formula: C7H9NOS
• Molecular Weight: 155.21746
• Mol File: 28783-49-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, DCM, Ethyl Acetate
• CAS DataBase Reference: N-[2-(2-Thienyl)ethyl]forMaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(2-Thienyl)ethyl]forMaMide(28783-49-5)
• EPA Substance Registry System: N-[2-(2-Thienyl)ethyl]forMaMide(28783-49-5)

Safety Data

• Hazardous Substances Data: 28783-49-5(Hazardous Substances Data)

Usage

Uses

N-[2-(2-Thienyl)ethyl]formamide is a sulfur analog of Isoquinolines. N-[2-(2-Thienyl)ethyl]formamide have been used in attempts to prepare analogs of papaverine (P190500).

Upstream product

• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 109-94-4 formic acid ethyl ester 
• 40412-06-4 2-(2-thienyl)ethyl tosylate 
• 77287-34-4 formamide 
• 5402-55-1 2-thiophenethanol 
• 64-18-6 formic acid 
• 20893-30-5 2-cyanomethylthiophene 

Downstream Products

• 107112-93-6 dihydro-6,7 thieno<3,2-c>pyridine 
• 106891-32-1 N-methyl-N-(2-(thien-2-yl)ethyl)amine 
• 602268-91-7 2-(thiophen-2-yl)ethyl isocyanide 

Relevant articles and documents

Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof

The present invention provides compounds that can enhance functional O-mannosylation of proteins including alpha-dystroglycan. Also provided are methods of preparation of the compounds defined by the formula I. Also provided are the methods of using the compounds or the pharmaceutical acceptable salts or prodrugs thereof in treating and preventing subjects suffering from the diseases including muscular dystrophies and cancers.

Small molecules enhance functional O-mannosylation of Alpha-dystroglycan

Alpha-dystroglycan (α-DG), a highly glycosylated receptor for extracellular matrix proteins, plays a critical role in many biological processes. Hypoglycosylation of α-DG results in various types of muscular dystrophies and is also highly associated with progression of majority of cancers. Currently, there are no effective treatments for those devastating diseases. Enhancing functional O-mannosyl glycans (FOG) of α-DG on the cell surfaces is a potential approach to address this unmet challenge. Based on the hypothesis that the cells can up-regulate FOG of α-DG in response to certain chemical stimuli, we developed a cell-based high-throughput screening (HTS) platform for searching chemical enhancers of FOG of α-DG from a large chemical library with 364,168 compounds. Sequential validation of the hits from a primary screening campaign and chemical works led to identification of a cluster of compounds that positively modulate FOG of α-DG on various cell surfaces including patient-derived myoblasts. These compounds enhance FOG of α-DG by almost ten folds, which provide us powerful tools for O-mannosylation studies and potential starting points for the development of drug to treat dystroglycanopathy.

Compounds with growth hormone releasing properties

There are disclosed novel synthetic peptides of the general formula (I) Compounds of formula (I) stimulate the release of growth hormone from the pituitary in humans and animals. A method for increasing the rate and extent of growth of animals to increase their milk and wool production or for the treatment of ailments, and the use of the compounds of formula (I) for the preparation of medicaments, are also disclosed.