[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane
CAS No.:347840-56-6
Molecular Formula:C₂₉H₃₅BrO₃Si
Molecular Weight:539.585
Hs Code.:

[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-<i>tert</i>-butyl-diphenyl-silane

Synonyms:[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

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Chemical Property of [2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

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Technology Process of [2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

There total 7 articles about [2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 870-63-3
prenyl bromide

: 347840-54-4
2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

: 347840-56-6
[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

: 347840-55-5
2-bromo-3-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxy-6-(3-methyl-but-2-enyl)-phenol

Guidance literature:: 2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol; With sodium hydride; In toluene; at 50 ℃; for 4h;

prenyl bromide; In toluene; at -30 ℃; for 12h; Further stages.;
DOI:10.1021/ol0159367

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 347840-56-6
[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / Br₂ / CHCl₃ / 1.5 h / 20 °C

2.1: 94 percent / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

3.1: 72 percent / NaH / tetrahydrofuran / 6 h / 65 °C

4.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

5.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

6.1: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

7.1: NaH / toluene / 4 h / 50 °C

7.2: 35 percent / toluene / 12 h / -30 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; bromine; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0159367

Reference yield:

: 241127-72-0
2-bromo-3,6-dihydroxy-benzaldehyde

: 347840-56-6
[2-bromo-6-methoxy-3-(3-methyl-but-2-enyloxy)-benzyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

2.1: 72 percent / NaH / tetrahydrofuran / 6 h / 65 °C

3.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

4.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

5.1: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

6.1: NaH / toluene / 4 h / 50 °C

6.2: 35 percent / toluene / 12 h / -30 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0159367