(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

Base Information

Chemical Name:(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone
CAS No.:1394029-21-0
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

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Chemical Property of (4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

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Technology Process of (4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

There total 4 articles about (4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1394030-86-4
(4'-hydroxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

: 75-26-3
isopropyl bromide

: 1394029-21-0
(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

Guidance literature:: (4'-hydroxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

isopropyl bromide; With dmap; In N,N-dimethyl-formamide; at 35 ℃;

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1394029-21-0
(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / acetic acid / 16 h / 20 °C

2.1: acetic anhydride / 64 h / Reflux

3.1: pyrrolidine / toluene / 17 h / 110 °C

4.1: hydrogenchloride / toluene; 1,4-dioxane / 0.67 h / 20 °C

5.1: triethylamine / dichloromethane / 0.25 h / 20 °C

5.2: 14 h / 20 °C

6.1: sodium tetrahydroborate; methanol / 0.58 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

7.2: 35 °C

With pyrrolidine; hydrogenchloride; methanol; sodium tetrahydroborate; dihydrogen peroxide; sodium hydride; triethylamine; methyltrioxorhenium(VII); In 1,4-dioxane; dichloromethane; acetic anhydride; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: spiro[3H-pyrano[2,3-b]pyridine-2,4'-piperidine]-4-one dihydrochloride

: 1394029-21-0
(4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 14 h / 20 °C

2.1: sodium tetrahydroborate; methanol / 0.58 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 35 °C

With methanol; sodium tetrahydroborate; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;