4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

Base Information

• Chemical Name: 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid
• CAS No.: 99558-84-6
• Molecular Formula: 2CH₄O₃S*C₂₄H₂₇N₃O₃
• Molecular Weight: 597.711
• Mol file: 99558-84-6.mol

Synonyms:4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

Chemical Property of 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

There total 5 articles about 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Amidino-2-naphthol (58200-88-7) → 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid (99558-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: 1.) dicyclohexylcarbodiimide (DCC) / 1.) pyridine, room temp.; 2.) H₂O

With dicyclohexyl-carbodiimide; In methanol;

DOI:10.1248/cpb.33.1458

Reference yield:

6-bromo-naphthalen-2-ol (15231-91-1) → 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid (99558-84-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / CuCN / dimethylformamide / 3 h / 160 - 170 °C

2: HCl / Ambient temperature

3: NH₃ / methanol / 3 h / 50 °C

4: methanol

5: 1.) dicyclohexylcarbodiimide (DCC) / 1.) pyridine, room temp.; 2.) H₂O

With hydrogenchloride; ammonia; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.1458

Reference yield:

6-cyano-2-naphthol (52927-22-7) → 4-(2-Diethylamino-ethoxy)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid (99558-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / Ambient temperature

2: NH₃ / methanol / 3 h / 50 °C

3: methanol

4: 1.) dicyclohexylcarbodiimide (DCC) / 1.) pyridine, room temp.; 2.) H₂O

With hydrogenchloride; ammonia; dicyclohexyl-carbodiimide; In methanol;

DOI:10.1248/cpb.33.1458

upstream raw materials:

4-(2-diethylamino-ethoxy)-benzoic acid

methanesulfonic acid sodium salt

6-amidino-2-naphthol methanesulfonate

6-bromo-naphthalen-2-ol