tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

Base Information

• Chemical Name: tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate
• CAS No.: 202214-53-7
• Molecular Formula: C₂₀H₃₂N₂O₅
• Molecular Weight: 380.484

Synonyms:tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

Chemical Property of tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

Chemical Property:

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Technology Process of tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

There total 2 articles about tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Boc-Tyr(t-Bu)-OH (47375-34-8) → tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (202214-53-7)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm100839w

Reference yield:

Boc-Tyr(t-Bu)-OH (47375-34-8) + N,0-dimethylhydroxylamine (1117-97-1) → tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (202214-53-7)

Guidance literature:

Boc-Tyr(t-Bu)-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Inert atmosphere;

N,0-dimethylhydroxylamine; With N-ethyl-N,N-diisopropylamine;

DOI:10.1021/jo201215c

Reference yield: 85.0%

tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (202214-53-7) → tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-oxoethyl]carbamate (74974-37-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 30h;

DOI:10.1021/jm100839w

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Boc-Tyr(t-Bu)-OH

N,0-dimethylhydroxylamine

Downstream raw materials:

tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-oxoethyl]carbamate

[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propylamino]-acetic acid methyl ester

(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-{[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-methoxycarbonylmethyl-amino}-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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