2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

Base Information

Chemical Name:2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate
CAS No.:1613414-02-0
Molecular Formula:CH₂O₂*C₅₀H₅₂N₄O₉
Molecular Weight:899.01
Hs Code.:

2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

Synonyms:2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

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Chemical Property of 2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

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Technology Process of 2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

There total 19 articles about 2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 64-18-6
formic acid

: 1415971-12-8
(R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride

: 1613414-01-9
2-(4-formyl-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate

: 1613414-02-0
2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

Guidance literature:: (R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride; With triethylamine; In methanol; acetonitrile; for 0.166667h;

2-(4-formyl-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate; In methanol; acetonitrile; at 20 ℃; for 1h;

formic acid; Further stages;

Reference yield:

: 948893-91-2
(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

: 1613414-02-0
2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; 2,5-dihydrotoluene / ethanol / 2 h / 60 °C

1.2: 18 h / 20 °C

2.1: triethylamine / methanol; acetonitrile / 0.17 h

2.2: 1 h / 20 °C

With 2,5-dihydrotoluene; palladium 10% on activated carbon; triethylamine; In methanol; ethanol; acetonitrile;

Reference yield:

: 1416069-95-8
N-((3-hydroxyphenyl)(phenyl)methyl)formamide

: 1613414-02-0
2-(4-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-2-methylphenoxy)ethyl 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoate formate

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetyl chloride; hydrogenchloride / methanol / 1.5 h / 0 - 40 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: diethylamine / isopropyl alcohol; n-heptane / 25 °C / Resolution of racemate

4.1: potassium carbonate / acetonitrile / 16 h / 20 °C

5.1: hydrogenchloride / methanol; 1,4-dioxane / 16 h / 20 °C

6.1: pyridine / 17 h / 0 - 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

8.2: 18 h / 20 °C

9.1: triethylamine / methanol; acetonitrile / 0.17 h

9.2: 1 h / 20 °C

With pyridine; hydrogenchloride; water; potassium carbonate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;