methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

Base Information

Chemical Name:methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate
CAS No.:1414357-46-2
Molecular Formula:C₄₁H₅₄N₆O₇
Molecular Weight:742.916
Hs Code.:

methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

Synonyms:methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

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Chemical Property of methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

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Technology Process of methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

There total 7 articles about methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1414357-91-7
methyl (S)-2-((S)-2-{2-[(S)-2-azidopropanamido]acetamido}-4-methylpentanamido)-3-phenylpropanoate

: 57-63-6
ethinyl estradiol

: 1414357-46-2
methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 96h;
DOI:10.1055/s-0032-1316702

Reference yield:

: 108456-25-3
methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

: 1414357-46-2
methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h / 20 °C

With hydrogenchloride; 1,2,3-Benzotriazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1055/s-0032-1316702

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 1414357-46-2
methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

2: hydrogenchloride / methanol / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

4: hydrogenchloride / methanol / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

6: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h / 20 °C

With hydrogenchloride; 1,2,3-Benzotriazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1055/s-0032-1316702