methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

Base Information

Chemical Name:methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate
CAS No.:108456-25-3
Molecular Formula:C₂₃H₃₅N₃O₆
Molecular Weight:449.547
Hs Code.:

Synonyms:methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

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Chemical Property of methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

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Technology Process of methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

There total 9 articles about methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 51871-42-2
(S)-2-(2-(tert-butoxycarbonylamino)acetamido)-4-methylpentanoic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 108456-25-3
methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1055/s-0035-1560523

Reference yield: 68.0%

: 4530-20-5
BOC-glycine

: 6461-07-0,37885-98-6
methyl (S)-2-[(S)-2-amino-4-methylpentanamido]-3-phenylpropanoate hydrochloride

: 108456-25-3
methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

Guidance literature:: With 1,2,3-Benzotriazole; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In acetonitrile; at 0 - 20 ℃;
DOI:10.1055/s-0032-1316702

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 108456-25-3
methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

2: hydrogenchloride / methanol / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

With hydrogenchloride; 1,2,3-Benzotriazole; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1055/s-0032-1316702