Technology Process of (2,4-bis(4-(methoxymethoxy)phenyl)but-3-ynyloxy)(tert-butyl)dimethylsilane
There total 8 articles about (2,4-bis(4-(methoxymethoxy)phenyl)but-3-ynyloxy)(tert-butyl)dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4-bis(4-(methoxymethoxy)phenyl)but-3-yn-1-ol;
With
1H-imidazole;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
tert-butyldimethylsilyl chloride;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.5012/bkcs.2013.34.4.1247
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / toluene / 24 h / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -50 - 0 °C / Inert atmosphere
4.2: 1 h
4.3: 0.5 h / -20 °C
5.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
5.2: 1 h / 20 °C
With
1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
1.1: |Sonogashira Cross-Coupling;
DOI:10.5012/bkcs.2013.34.4.1247
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: sodium hydride / mineral oil; dimethyl sulfoxide; hexane / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 0.17 h / 20 °C / Inert atmosphere; Cooling with ice
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -50 - 0 °C / Inert atmosphere
3.2: 1 h
3.3: 0.5 h / -20 °C
4.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
4.2: 1 h / 20 °C
With
1H-imidazole; n-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; mineral oil;
2.1: |Johnson-Corey-Chaykovsky Reaction / 2.2: |Johnson-Corey-Chaykovsky Reaction;
DOI:10.5012/bkcs.2013.34.4.1247
