phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:952423-59-5
Molecular Formula:C₂₇H₃₃F₃N₂O₃S
Molecular Weight:522.632
Hs Code.:

Synonyms:phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 8 articles about phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 952423-58-4
C₂₀H₂₈N₂O₃S

: 157911-56-3
2,4,5-trifluorobenzyl bromide

: 952423-59-5
phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

: 952506-22-8
phenylmethyl (3-exo)-3-[(1S)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: 2,4,5-trifluorobenzyl bromide; With iodine; magnesium; In cyclopentyl methyl ether; toluene; at 20 - 28 ℃; Inert atmosphere;

C₂₀H₂₈N₂O₃S; In dichloromethane; cyclopropyl methyl ether; toluene; at -55 - 20 ℃; diastereoselective reaction;
DOI:10.1021/jo801830x

Reference yield:

: 3-exo-{[(S)-2-methyl-propane-2-sulfinylimino]-methyl}-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid benzyl ester

: 952423-59-5
phenylmethyl (3-exo)-3-[(1R)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

: 952506-22-8
phenylmethyl (3-exo)-3-[(1S)-1-[[(S)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2,4,5-trifluorophenyl)ethyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: 2,4,5-trifluorobenzyl bromide; With magnesium; In diethyl ether; at 20 ℃; for 0.5h;

3-exo-{[(S)-2-methyl-propane-2-sulfinylimino]-methyl}-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid benzyl ester; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 4h;

With water; ammonium chloride; In diethyl ether; dichloromethane; at 0 ℃;