N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

Base Information

Chemical Name:N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine
CAS No.:131132-31-5
Molecular Formula:C₂₉H₄₃N₅O₇Si₂
Molecular Weight:629.861
Hs Code.:

N<sup>3</sup>-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

Synonyms:N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

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Chemical Property of N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

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Technology Process of N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

There total 2 articles about N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 131132-30-4
N³-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl disiloxane-1,3-diyl)5-methyluridine

: 131132-31-5
N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

Guidance literature:: With diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1021/jm00107a018

Reference yield:

: 130983-87-8
1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione

: 131132-31-5
N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 70 percent / diethyl azodicarboxylate, triphenyl phosphorazidate, triphenylphosphine / tetrahydrofuran / 4 h / Ambient temperature

With diphenylphosphoranyl azide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00107a018

Reference yield:

: 131132-31-5
N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

: 131132-34-8
2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / concd. NH₄OH / methanol / 1.5 h / Ambient temperature

2: tetrabutylammonium bromide, 0.2 M aq. NaHCO₃ / CH₂Cl₂ / 6.5 h / Ambient temperature

With ammonium hydroxide; tetrabutylammomium bromide; sodium hydrogencarbonate; In methanol; dichloromethane;
DOI:10.1021/jm00107a018