4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

Base Information

• Chemical Name: 4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide
• CAS No.: 880614-87-9
• Molecular Formula: C₁₂H₉ClFN₃OS
• Molecular Weight: 297.74

Synonyms:4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

Chemical Property of 4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

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Technology Process of 4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

There total 1 articles about 4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-fluoroaniline (371-40-4) + 4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride (55084-66-7) → 4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide (880614-87-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.25h;

Reference yield: 80.0%

4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide (880614-87-9) + N-BOC-1,2-diaminoethane (57260-73-8) → {2-[5-(4-Fluorophenylcarbamoyl)-2-methylsulfanylpyrimidin-4-ylamino]-ethyl}carbamic acid tert-butyl ester (923292-81-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield: 78.0%

4-chloro-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide (880614-87-9) + 2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → 4-(2-hydroxy-2-phenylethylamino)-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide (923292-93-7)

Guidance literature:

In methanol; at 20 ℃; for 16h;

upstream raw materials:

4-fluoroaniline

4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Downstream raw materials:

{2-[5-(4-Fluorophenylcarbamoyl)-2-methylsulfanylpyrimidin-4-ylamino]-ethyl}carbamic acid tert-butyl ester

4-(2-hydroxy-2-phenylethylamino)-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

4-(1,1-Dioxotetrahydrothiophen-3-ylamino)-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide

2-Methylsulfanyl-4-(2-(phenylamino)phenylamino)pyrimidine-5-carboxylic acid (4-fluorophenyl)amide

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