2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI)

Base Information

• Chemical Name: 2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI)
• CAS No.: 103794-02-1
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.222
• Mol file: 103794-02-1.mol

Synonyms:2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI)

Chemical Property of 2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI)

Chemical Property:

• PSA: 49.41000
• LogP: 0.07210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI)

There total 3 articles about 2-Azabicyclo[2.1.1]hexane-1-carboxamide,2-acetyl-N-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azabicyclo[2.1.1]hexane-1-carboxylic acid (73550-56-8) → Ac-2,4-MePro-NHMe (103794-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / 16 h / Heating

2: triethylamine / CH₂Cl₂

3: H₂O / 3 h / Heating

With triethylamine; In dichloromethane; water; benzene;

DOI:10.1021/ja00281a051

Reference yield:

2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid (103794-05-4) → Ac-2,4-MePro-NHMe (103794-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂

2: H₂O / 3 h / Heating

With triethylamine; In dichloromethane; water;

DOI:10.1021/ja00281a051

Reference yield:

2-Acetyl-2-aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester (103794-06-5) + methylamine (74-89-5) → Ac-2,4-MePro-NHMe (103794-02-1)

Guidance literature:

In water; for 3h; Heating;

DOI:10.1021/ja00281a051

upstream raw materials:

2-Acetyl-2-aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester

methylamine

2-azabicyclo[2.1.1]hexane-1-carboxylic acid

2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid