3-Amino-butyric acid methyl ester

Base Information

• Chemical Name: 3-Amino-butyric acid methyl ester
• CAS No.: 103189-63-5
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.148
• Mol file: 103189-63-5.mol

Synonyms:Butanoicacid, 3-amino-, methyl ester, (R)-; (R)-3-Aminobutanoic acid methyl ester;Methyl (3R)-aminobutanoate

Chemical Property of 3-Amino-butyric acid methyl ester

Chemical Property:

• Vapor Pressure: 2.46mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 159.795°C at 760 mmHg
• PKA: 8.71±0.10(Predicted)
• Flash Point: 33.959°C
• PSA: 52.32000
• Density: 0.988g/cm³
• LogP: 0.59700
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

≥99% ^*data from raw suppliers

(R)?-?Methyl3-?aminobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)?-?Methyl 3-?aminobutanoate is a useful reactant for the stereoselective synthesis of N-?Unprotected β-?Amino Esters.

Technology Process of 3-Amino-butyric acid methyl ester

There total 38 articles about 3-Amino-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

methanol (67-56-1) + (R)-3-aminobutanoic acid (3775-73-3) → (R)-methyl 3-aminobutanoate hydrochloride (6078-06-4,83509-89-1,102522-53-2,103189-63-5)

Guidance literature:

With thionyl chloride; at 0 - 10 ℃; Reflux;

Reference yield: 90.0%

(3R,1'S)-3-<(1'-phenylethyl)amino>butanoic acid methyl ester (64838-60-4,1156032-60-8) → (R)-methyl 3-aminobutanoate hydrochloride (6078-06-4,83509-89-1,102522-53-2,103189-63-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 50 ℃; for 25h; under 22800 Torr;

Reference yield: 84.0%

methyl (R)-3-azidobutyrate → (R)-methyl 3-aminobutanoate hydrochloride (6078-06-4,83509-89-1,102522-53-2,103189-63-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 14h; under 2844.39 Torr;

DOI:10.1002/anie.201914896

upstream raw materials:

methanol

L-3-aminobutyric acid

chloro-trimethyl-silane

(S)-3-((S)-1-Phenyl-ethylamino)-butyric acid methyl ester

Downstream raw materials:

L-3-aminobutyric acid

(S)-methyl 3-(tert-butyloxycarbonylamino)butyrate

(3S)-3-aminobutanoic acid hydrochloride

(S)-(+)-N-(3-phenylaminobutyryl)benzoic acid

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