Technology Process of 3-bromo-5-ethoxy-N-methoxy-N-methylbenzamide
There total 3 articles about 3-bromo-5-ethoxy-N-methoxy-N-methylbenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 14h;
Inert atmosphere;
DOI:10.1021/jm200640v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; lithium hydroxide / tetrahydrofuran / 23 h / 20 °C
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere
With
water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200640v
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 100 °C / Inert atmosphere
2: water; lithium hydroxide / tetrahydrofuran / 23 h / 20 °C
3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere
With
water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200640v
