7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

Base Information

Chemical Name:7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin
CAS No.:427880-48-6
Molecular Formula:C₁₉H₁₅BrF₃NO₄S
Molecular Weight:490.298
Hs Code.:

Synonyms:7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

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Chemical Property of 7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

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Technology Process of 7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

There total 4 articles about 7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 106-93-4
ethylene dibromide

: 427880-47-5
7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin

: 427880-48-6
7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 14h;
DOI:10.1021/ja0175643

Reference yield:

: 53518-15-3
Coumarin 151

: 427880-48-6
7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 86 percent / cesium carbonate / acetonitrile / 14 h / 80 °C

With pyridine; caesium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/ja0175643

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 427880-48-6
7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 86 percent / cesium carbonate / acetonitrile / 14 h / 80 °C

With pyridine; caesium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/ja0175643