7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin

Base Information

• Chemical Name: 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin
• CAS No.: 427880-47-5
• Molecular Formula: C₁₇H₁₂F₃NO₄S
• Molecular Weight: 383.348
• Mol file: 427880-47-5.mol

Synonyms:7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin

Chemical Property of 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin

There total 1 articles about 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Coumarin 151 (53518-15-3) + p-toluenesulfonyl chloride (98-59-9) → 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin (427880-47-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ja0175643

Reference yield: 86.0%

ethylene dibromide (106-93-4) + 7-[N-(p-toluenesulfonyl)amino]-4-trifluoromethylcoumarin (427880-47-5) → 7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin (427880-48-6)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 14h;

DOI:10.1021/ja0175643

upstream raw materials:

Coumarin 151

p-toluenesulfonyl chloride

Downstream raw materials:

7-[N-(2-bromoethyl)-N-(p-toluenesulfonyl)amino]-4-trifluoro-methyl coumarin