N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide

Base Information

• Chemical Name: N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide
• CAS No.: 289686-54-0
• Molecular Formula: C₂₅H₁₈ClF₆NO₂
• Molecular Weight: 513.867
• Mol file: 289686-54-0.mol

Synonyms:N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide

Chemical Property of N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide

There total 1 articles about N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-chloro-2-aminobenzophenone (719-59-5) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide (289686-54-0)

Guidance literature:

5-chloro-2-aminobenzophenone; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

With dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; at 80 ℃;

Reference yield: 32.0%

N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide (289686-54-0) + methyl iodide (74-88-4) → N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide

Guidance literature:

N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 80 ℃;

upstream raw materials:

5-chloro-2-aminobenzophenone

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid