N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

Base Information

Chemical Name:N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide
CAS No.:1615725-16-0
Molecular Formula:C₂₃H₂₅FN₆O
Molecular Weight:420.49
Hs Code.:

Synonyms:N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

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Chemical Property of N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

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Technology Process of N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

There total 5 articles about N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 107-10-8,42939-71-9
propylamine

: 1615730-51-2
N-(6-formylimidazo[1,2-b]pyridazin-2-yl)pivalamide

: 165806-95-1
1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene

: 1615725-16-0
N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

Guidance literature:: propylamine; N-(6-formylimidazo[1,2-b]pyridazin-2-yl)pivalamide; With N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene; With potassium carbonate; at 20 ℃;

Reference yield:

: 1615730-47-6
N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)pivalamide

: 1615725-16-0
N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C / 7757.43 Torr / Autoclave

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 8.33 h / Cooling with acetone-dry ice

3.1: N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; diisobutylaluminium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1615725-16-0
N-(6-(4-(4-fluorophenyl)-1-propyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl acetamide / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 85 °C / 7757.43 Torr / Autoclave

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 8.33 h / Cooling with acetone-dry ice

4.1: N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; diisobutylaluminium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;