(S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate
• CAS No.: 1033883-20-3
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.324
• Mol file: 1033883-20-3.mol

Synonyms:(S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate

Chemical Property of (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate

There total 2 articles about (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methylamine hydrochloride (593-51-1) + (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate (1033883-20-3)

Guidance literature:

methylamine hydrochloride; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 18h;

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) + methylamine (74-89-5) → (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate (1033883-20-3)

Guidance literature:

With benzotriazol-1-ol;

DOI:10.1021/ol030104p

Reference yield:

(S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate (1033883-20-3) → (S)-2-amino-N-methyl-2-phenylacetamide (129213-83-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.666667h;

DOI:10.1021/jo0517848

upstream raw materials:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

methylamine

methylamine hydrochloride

Downstream raw materials:

(S)-2-amino-N-methyl-2-phenylacetamide

L-isoleucyl-L-phenylglycine methyl amide