2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Base Information

• Chemical Name: 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide
• CAS No.: 1147874-51-8
• Molecular Formula: C₂₁H₁₈ClFN₄O₂
• Molecular Weight: 412.851
• Mol file: 1147874-51-8.mol

Synonyms:2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Chemical Property of 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

There total 2 articles about 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-42-7) + ethyl iodide (75-03-6) → 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-51-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 15h;

DOI:10.1016/j.ejmech.2008.07.024

Reference yield:

8-amino-6-fluoro-4-hydroxy-7-methylaminoquinoline-3-carboxylic acid methylamide (1147874-38-1) + para-chlorobenzoic acid (74-11-3) → 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: PPA / 100 - 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 - 90 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.812

upstream raw materials:

2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

ethyl iodide

8-amino-6-fluoro-4-hydroxy-7-methylaminoquinoline-3-carboxylic acid methylamide

para-chlorobenzoic acid