2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Base Information

• Chemical Name: 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide
• CAS No.: 1147874-42-7
• Molecular Formula: C₁₉H₁₄ClFN₄O₂
• Molecular Weight: 384.797

Synonyms:2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Chemical Property of 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

Chemical Property:

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Technology Process of 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

There total 2 articles about 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.2%

8-amino-6-fluoro-4-hydroxy-7-methylaminoquinoline-3-carboxylic acid methylamide (1147874-38-1) + 4-chlorobenzaldehyde (104-88-1) → 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-42-7) + 2-(4-chlorophenyl)-8-fluoro-9-methylamino-6-oxo-6H-imidazo[4,5,1-ij]quinoline-5-carboxylic acid methylamide (927822-51-3)

Guidance literature:

With acetic acid; for 4h; Reflux;

DOI:10.1016/j.ejmech.2008.07.024

Reference yield:

8-amino-6-fluoro-4-hydroxy-7-methylaminoquinoline-3-carboxylic acid methylamide (1147874-38-1) + para-chlorobenzoic acid (74-11-3) → 2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-42-7)

Guidance literature:

With PPA; at 100 - 110 ℃;

DOI:10.1002/jhet.812

Reference yield: 87.0%

2-(4-chlorophenyl)-4-fluoro-6-hydroxy-3-methyl-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-42-7) + ethyl iodide (75-03-6) → 2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide (1147874-51-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 15h;

DOI:10.1016/j.ejmech.2008.07.024

upstream raw materials:

8-amino-6-fluoro-4-hydroxy-7-methylaminoquinoline-3-carboxylic acid methylamide

4-chlorobenzaldehyde

para-chlorobenzoic acid

Downstream raw materials:

2-(4-chlorophenyl)-9-ethyl-4-fluoro-3-methyl-6-oxo-6,9-dihydro-3H-imidazo[4,5-h]quinoline-7-carboxylic acid methylamide

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