(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

Base Information

Chemical Name:(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione
CAS No.:1438394-44-5
Molecular Formula:C₂₈H₂₄BrNO₂
Molecular Weight:486.408
Hs Code.:

Synonyms:(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

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Chemical Property of (2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

Chemical Property:

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Technology Process of (2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

There total 8 articles about (2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1438394-24-1
N-benzyl-1-oxo-N-(penta-3,4-dien-1-yl)indane-2-carboxamide

: C₂₁H₂₀N₂O₂

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1438394-44-5
(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

: 162997-33-3
tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate

: 162997-34-4
4-(piperidin-4-yl)benzonitrile hydrochloride

Guidance literature:: With potassium phosphate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 90 ℃; for 43h; Overall yield = 78 %; Overall yield = 197.1 mg; enantioselective reaction; Inert atmosphere; Schlenk technique; Molecular sieve;
DOI:10.1039/c3cc40892b

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1438394-24-1
N-benzyl-1-oxo-N-(penta-3,4-dien-1-yl)indane-2-carboxamide

: C₂₁H₂₀N₂O₂

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1438394-44-5
(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

: 162997-33-3
tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate

: 162997-34-4
4-(piperidin-4-yl)benzonitrile hydrochloride

: C₂₁H₂₀N₂O₂

Guidance literature:: With potassium phosphate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 90 ℃; for 43h; Overall yield = 78 %; Overall yield = 197.1 mg; enantioselective reaction; Inert atmosphere; Schlenk technique; Molecular sieve;
DOI:10.1039/c3cc40892b

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1438394-24-1
N-benzyl-1-oxo-N-(penta-3,4-dien-1-yl)indane-2-carboxamide

: C₂₁H₂₀N₂O₂

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1438394-44-5
(2R,4'S)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

: 162997-33-3
tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate

: 162997-34-4
4-(piperidin-4-yl)benzonitrile hydrochloride

: C₂₁H₂₀N₂O₂

: (2S,4'R)-1'-benzyl-4'-[1-(4-bromophenyl)vinyl]-2'Hspiro[indene-2,3'-piperidine]-1,2'(3H)-dione

Guidance literature:: With potassium phosphate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 90 ℃; for 43h; Overall yield = 78 %; Overall yield = 197.1 mg; enantioselective reaction; Inert atmosphere; Schlenk technique; Molecular sieve;
DOI:10.1039/c3cc40892b