4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester
CAS No.:83704-95-4
Molecular Formula:C₁₇H₂₇F₃N₂O₅
Molecular Weight:396.407
Hs Code.:

Synonyms:4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of 4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

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Technology Process of 4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

There total 8 articles about 4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83704-94-3
1-azido-4--2,2-(ethylenedioxy)butane

: 83704-95-4
4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; for 18h; under 517.1 Torr;
DOI:10.1021/jm00356a004

Reference yield:

: 6959-76-8
3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid

: 83704-95-4
4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / H₂ / PtO₂ / acetic acid / 18 h / 2327.2 Torr

2: 90 percent / 18 h / Ambient temperature

3: thionyl chloride / benzene / 1 h / Heating

4: diethyl ether / 1 h / 25 °C

5: HBr / diethyl ether

6: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

7: p-toluenesulfonic acid / benzene / 6 h / Heating

8: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

With thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; water; acetic acid; benzene;
DOI:10.1021/jm00356a004

Reference yield:

: 83704-89-6
N-(4-carbethoxycyclohexyl)-β-alanine

: 83704-95-4
4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / 18 h / Ambient temperature

2: thionyl chloride / benzene / 1 h / Heating

3: diethyl ether / 1 h / 25 °C

4: HBr / diethyl ether

5: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

6: p-toluenesulfonic acid / benzene / 6 h / Heating

7: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

With thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; diethyl ether; water; benzene;
DOI:10.1021/jm00356a004