2-chloro-6-(trifluoromethoxy)nicotinic acid

Base Information Edit

Chemical Name:2-chloro-6-(trifluoromethoxy)nicotinic acid
CAS No.:1221172-04-8
Molecular Formula:C₇H₃ClF₃NO₃
Molecular Weight:241.554
Hs Code.:2933399990
Mol file:1221172-04-8.mol

Synonyms:2-chloro-6-(trifluoromethoxy)nicotinic acid

Suppliers and Price of 2-chloro-6-(trifluoromethoxy)nicotinic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Chloro-6-(trifluoromethoxy)nicotinicacid 95+%
1g
$ 772.00

Chemenu
2-Chloro-6-(trifluoromethoxy)nicotinicacid 95%
1g
$ 729.00

American Custom Chemicals Corporation
2-CHLORO-6-(TRIFLUOROMETHOXY)NICOTINIC ACID 95.00%
5MG
$ 503.75

Total 17 raw suppliers

Chemical Property of 2-chloro-6-(trifluoromethoxy)nicotinic acid Edit

Chemical Property:

Boiling Point:261.7±35.0 °C(Predicted)
PKA:1.62±0.28(Predicted)
Density:1.637±0.06 g/cm3(Predicted)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-6-(trifluoromethoxy)nicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-(trifluoromethoxy)nicotinic acid

There total 7 articles about 2-chloro-6-(trifluoromethoxy)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1221172-02-6
2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine

: 1221172-04-8
2-chloro-6-(trifluoromethoxy)nicotinic acid

Guidance literature:: 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

carbon dioxide; With sodium hydroxide; In tetrahydrofuran; water; hexan-1-ol;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 20h;
DOI:10.1016/j.jfluchem.2017.08.006

Reference yield:

: 1221171-70-5
2-chloro-6-(trifluoromethoxy)pyridine

: 1221172-04-8
2-chloro-6-(trifluoromethoxy)nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

1.2: 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.3: pH 5

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 1384878-23-2
2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)nicotinic acid

: 1221172-04-8
2-chloro-6-(trifluoromethoxy)nicotinic acid

Guidance literature:: 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)nicotinic acid; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 20h;

With hydrogenchloride; In tetrahydrofuran; water;