3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

Base Information

Chemical Name:3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde
CAS No.:478910-78-0
Molecular Formula:C₃₄H₃₈O₅Si
Molecular Weight:554.758
Hs Code.:

Synonyms:3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

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Chemical Property of 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

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Technology Process of 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

There total 7 articles about 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 478910-90-6
{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5,6,4'-trimethoxy-biphenyl-2-yl}-methanol

: 478910-78-0
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 20 ℃;
DOI:10.1021/jo026337w

Reference yield:

: 85010-19-1
4,4-dimethyl-2-(2,3,4-trimethoxyphenyl)-4,5-oxazoline

: 478910-78-0
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -10 - 20 °C

2: 90 percent / aq. HCl / 0.33 h / Heating

3: 100 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / -78 °C

4: 75 percent / imidazole / dimethylformamide / 0.33 h / 20 °C

5: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With 1H-imidazole; hydrogenchloride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo026337w

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 478910-78-0
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -10 - 20 °C

2: 90 percent / aq. HCl / 0.33 h / Heating

3: 100 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / -78 °C

4: 75 percent / imidazole / dimethylformamide / 0.33 h / 20 °C

5: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With 1H-imidazole; hydrogenchloride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo026337w