18087-99-5

Basic information

• Product Name: (4,6-Dimethylpyridin-2-yl)methanol
• Synonyms: (4,6-Dimethylpyridin-2-yl)methanol
• CAS NO: 18087-99-5
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137
• EINECS: 604-604-1
• Mol File: 18087-99-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4,6-Dimethylpyridin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4,6-Dimethylpyridin-2-yl)methanol(18087-99-5)
• EPA Substance Registry System: (4,6-Dimethylpyridin-2-yl)methanol(18087-99-5)

Safety Data

• Hazardous Substances Data: 18087-99-5(Hazardous Substances Data)

Usage

General Description

(4,6-Dimethylpyridin-2-yl)methanol is a chemical compound with the molecular formula C9H11NO. It is a type of alcohol that contains a pyridine ring, which gives it unique properties. (4,6-Dimethylpyridin-2-yl)methanol is often used in organic synthesis and pharmaceutical research as a building block for the synthesis of various chemical compounds. It can also be employed as a reagent in organic reactions, such as in the formation of esters or ethers. Additionally, (4,6-Dimethylpyridin-2-yl)methanol has potential applications in the development of new drugs and therapeutic agents due to its pharmacological properties. Overall, this chemical compound plays a significant role in the field of organic chemistry and pharmaceutical science.

Upstream product

• 67-56-1 methanol 
• 108-47-4 2,4-lutidine 
• 20609-14-7 (4,6-dimethylpyridin-2-yl)methyl acetate 
• 80206-42-4 4,6-dimethylpyridine-2-carboxylic acid ethyl ester 
• 7584-11-4 4,6-dimethylpyridine-2-carbonitrile 
• 3376-50-9 2,4,6-trimethyl-pyridine 1-oxide 
• 755014-26-7 C₁₀H₁₀F₃NO₂ 
• 108-75-8 2,4,6-trimethyl-pyridine 
• 1122-45-8 2,4-dimethylpyridine N-oxide 
• 107264-00-6 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate 

Downstream Products

• 5439-01-0 4,6-dimethylpyridine-2-carbaldehyde 
• 1029803-70-0 (4,6-dimethylpyridin-2-ylmethyl)(4-nitrophenyl)amine 
• 18088-10-3 4,6-dimethylpyridine-2-carboxylic acid 

Relevant articles and documents

A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motor neurons and skeletal muscle atrophy. The majority of ALS cases are acquired spontaneously, with inherited disease accounting for only 10 % of all cases. Recent studies provide compelling evidence that aggregates of misfolded proteins underlie both types of ALS. Small molecules such as artificial chaperones can prevent or even reverse the aggregation of proteins associated with various human diseases. However, their very high active concentration (micromolar range) severely limits their utility as drugs. We synthesized several ester and amide derivatives of chemical chaperones. The lead compound 14, 3-((5-((4,6-dimethylpyridin-2-yl)methoxy)-5-oxopentanoyl)oxy)-N,N-dimethylpropan-1-amine oxide shows, in the micromolar concentration range, both neuronal and astrocyte protective effects in vitro; at daily doses of 10 mg kg-1 14 improved the neurological functions and delayed body weight loss in ALS mice. Members of this new chemical chaperone derivative class are strong candidates for the development of new drugs for ALS patients.

Fe(PyTACN)-catalyzed cis-dihydroxylation of olefins with hydrogen peroxide

A family of iron complexes with general formula [Fe(II)( R,Y,XPyTACN)(CF3SO3)2], where R,Y,XPyTACN=1-[2′-(4-Y-6-X-pyridyl)methyl]-4,7-dialkyl-1,4, 7-triazacyclononane, X and Y refer to the groups at positions 4 and 6 of the pyridine, respectively, and R refers to the alkyl substitution at N-4 and N-7 of the triazacyclononane ring, are shown to be catalysts for efficient and selective alkene oxidation (epoxidation and cis-dihydroxylation) employing hydrogen peroxide as oxidant. Complex [Fe(II)(Me,Me,HPyTACN)(CF 3SO3)2] (7), was identified as the most efficient and selective cis-dihydroxylation catalyst among the family. The high activity of 7 allows the oxidation of alkenes to proceed rapidly (30 min) at room temperature and under conditions where the olefin is not used in large amounts but instead is the limiting reagent. In the presence of 3 mol% of 7, 2 equiv. of H2O2 as oxidant and 15 equiv. of water, in acetonitrile solution, alkenes are cis-dihydroxylated reaching yields that might be interesting for synthetic purposes. Competition experiments show that 7 exhibits preferential selectivity towards the oxidation of cis olefins over the trans analogues, and also affords better yields and high [syn-diol]/[epoxide] ratios when cis olefins are oxidized. For aliphatic substrates, reaction yields attained with the present system compare favourably with state of the art Fe-catalyzed cis-dihydroxylation systems, and it can be regarded as an attractive complement to the iron and manganese systems described recently and which show optimum activity against electron-deficient and aromatic olefins. Copyright

2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.