N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

Base Information

Chemical Name:N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide
CAS No.:1056555-53-3
Molecular Formula:C₃₃H₃₈Cl₃NO₅
Molecular Weight:635.027
Hs Code.:

Synonyms:N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

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Chemical Property of N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

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Technology Process of N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

There total 9 articles about N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 921630-23-1
N-[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropanamine

: 1056555-52-2
2-(4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl)-3-hydroxybutanoic acid

: 1056555-53-3
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 2432-12-4
2,6-dichloro-4-methylophenol

: 1056555-53-3
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / 4 h / 150 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

3.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

5.2: 15.25 h / -78 - 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

7.1: methanol; lithium hydroxide; water / 12 h / 20 °C

7.2: pH ~ 2

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; tributylphosphine; water; iodine; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 921630-64-0
2-(2,6-dichloro-4-methyl-phenoxy)-ethanol

: 1056555-53-3
N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-hydroxybutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 1.75 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - -40 °C

4.2: 15.25 h / -78 - 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 20 °C

6.1: methanol; lithium hydroxide; water / 12 h / 20 °C

6.2: pH ~ 2

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With 1H-imidazole; methanol; lithium hydroxide; sodium tetrahydroborate; tributylphosphine; water; iodine; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;