7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine

Base Information

• Chemical Name: 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine
• CAS No.: 1415415-01-8
• Molecular Formula: C₁₀H₉FN₂O
• Molecular Weight: 192.193
• Mol file: 1415415-01-8.mol

Synonyms:7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine

Chemical Property of 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

7-Fluoro-2-methoxy-8-methyl-1,5-naphthyridine 95+% ^*data from reagent suppliers

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Technology Process of 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine

There total 26 articles about 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9) + methyl iodide (74-88-4) → 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine (1415415-01-8)

Guidance literature:

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine; With n-hexyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; for 1h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/op500100b

Reference yield: 83.0%

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine (724788-70-9) + dihydroxy-methyl-borane (13061-96-6) → 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine (1415415-01-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 100h;

DOI:10.1021/ml500069w

Reference yield: 76.0%

7-fluoro-2-methoxy-1,5-naphthyridine (1003944-32-8) + methyl iodide (74-88-4) → 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine (1415415-01-8)

Guidance literature:

7-fluoro-2-methoxy-1,5-naphthyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -75 - -70 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -74 - -72 ℃; for 1h;

DOI:10.1021/op500100b

upstream raw materials:

8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine

dihydroxy-methyl-borane

t-butyl 4-bromo-6-methoxy-1,5-naphthyridine-3-yl-carbamate

4-bromo-6-(methyloxy)-1,5-naphthyridin-3-amine

Downstream raw materials:

t-butyl 1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl)-2-oxabicyclo[2.2.2]octan-4-ylcarbamate

t-butyl 1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl)-2-oxabicyclo[2.2.2]octan-4-ylcarbamate

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