(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Base Information

Chemical Name:(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid
CAS No.:1541197-12-9
Molecular Formula:C₂₆H₃₀F₃N₅O₇
Molecular Weight:581.549
Hs Code.:

(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Synonyms:(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

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Chemical Property of (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

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Technology Process of (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

There total 11 articles about (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541199-09-0
(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

: 1541197-12-9
(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In water; acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

: 1541197-12-9
(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile; water

2.1: hydrogenchloride / 2 h / 20 °C

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate / acetonitrile; water / 2 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-ol; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid trifluoroacetate

: 1541197-12-9
(3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / acetonitrile; water / 2 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-ol; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;