(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Base Information

Chemical Name:(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid
CAS No.:1541199-06-7
Molecular Formula:C₁₃H₁₆F₃NO₃
Molecular Weight:291.27
Hs Code.:

Synonyms:(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

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Chemical Property of (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Chemical Property:

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Technology Process of (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

There total 5 articles about (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541197-80-1
3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: With potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water; at 20 ℃; for 63h; pH=8.2; Enzymatic reaction;

Reference yield:

: 477535-41-4
3-bromo-5-(trifluoromethyl)benzaldehyde

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Dean-Stark; Reflux

2.1: n-butyllithium / diethyl ether / 0.83 h / -78 °C

2.2: 1 h / -78 °C

3.1: toluene-4-sulfonic acid / acetone / 4 h / 25 °C

4.1: ammonium formate / ethanol / 4 h / 50 °C

4.2: 0.42 h / 0 °C

5.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 63 h / 20 °C / pH 8.2 / Enzymatic reaction

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium formate; toluene-4-sulfonic acid; sodium hydroxide; In diethyl ether; ethanol; water; acetone; toluene;

Reference yield:

: 1541197-86-7
3-(1-hydroxy-1-methylethyl)-5-trifluoromethylbenzaldehyde

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / ethanol / 4 h / 50 °C

1.2: 0.42 h / 0 °C

2.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 63 h / 20 °C / pH 8.2 / Enzymatic reaction

With potassium dihydrogenphosphate; Amano Lipase PS; ammonium formate; sodium hydroxide; In ethanol; water;