(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Base Information

Chemical Name:(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate
CAS No.:1541199-09-0
Molecular Formula:C₂₈H₃₄F₃N₅O₇
Molecular Weight:609.602
Hs Code.:

(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Synonyms:(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Chemical Property of (3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Technology Process of (3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

There total 10 articles about (3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

: 1541199-08-9
(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

: 1541199-09-0
(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid; (S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

: 1541199-09-0
(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile; water

2.1: hydrogenchloride / 2 h / 20 °C

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid trifluoroacetate

: 1541199-09-0
(3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide;