(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

Base Information

Chemical Name:(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride
CAS No.:1541199-08-9
Molecular Formula:C₁₅H₂₀F₃NO₃*ClH
Molecular Weight:355.785
Hs Code.:

Synonyms:(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

Chemical Property:

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Technology Process of (S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

There total 7 articles about (S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid trifluoroacetate

: 1541199-08-9
(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

Guidance literature:: With hydrogenchloride; at 20 ℃; for 2h;

Reference yield:

: 1541199-06-7
(S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

: 1541199-08-9
(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile; water

2: hydrogenchloride / 2 h / 20 °C

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 1541197-82-3
2-(3-bromo-5-(trifluoromethyl)phenyl)-[1,3]dioxolane

: 1541199-08-9
(S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / diethyl ether / 0.83 h / -78 °C

1.2: 1 h / -78 °C

2.1: toluene-4-sulfonic acid / acetone / 4 h / 25 °C

3.1: ammonium formate / ethanol / 4 h / 50 °C

3.2: 0.42 h / 0 °C

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 63 h / 20 °C / pH 8.2 / Enzymatic reaction

5.1: acetonitrile; water

6.1: hydrogenchloride / 2 h / 20 °C

With hydrogenchloride; potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium formate; toluene-4-sulfonic acid; sodium hydroxide; In diethyl ether; ethanol; water; acetone; acetonitrile;