Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI)

Base Information

• Chemical Name: Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI)
• CAS No.: 16952-64-0
• Molecular Formula: C7H5 N3 O
• Molecular Weight: 147.1341
• Hs Code.: 2933990090
• Mol file: 16952-64-0.mol

Synonyms:Pyrido[4,3-d]pyrimidin-4(1H)-one(9CI); Pyrido[4,3-d]pyrimidin-4-ol (6CI,7CI); 3H-Pyrido[4,3-d]pyrimidin-4-one;4-Hydroxypyrido[4,3-d]pyrimidine

Chemical Property of Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI)

Chemical Property:

• Melting Point: 293 °C(Solv: water (7732-18-5))
• Boiling Point: 346.2±34.0 °C(Predicted)
• PKA: 4.01±0.20(Predicted)
• PSA: 58.90000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 0.73040

Purity/Quality:

99%, ^*data from raw suppliers

Pyrido[4,3-D]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI)

There total 8 articles about Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-amino-3-ethoxycarbonylpyridine (16952-66-2) + formamidine (463-52-5) → pyrido[4,3-d]pyrimidin-4(3H)-one (16952-64-0)

Guidance literature:

at 170 ℃; for 16h;

DOI:10.1016/j.tetlet.2004.03.088

Reference yield: 47.0%

4-aminonicotinic acid (7418-65-7) → pyrido[4,3-d]pyrimidin-4(3H)-one (16952-64-0)

Guidance literature:

In chloroform; formamide;

Reference yield:

4-amino-1-ethylpyrazolo[3,4-b]-pyridin-5-carboxamide (66550-76-3) + 4-amino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (34966-16-0) + orthoformic acid triethyl ester (122-51-0) → 7-ethyl-3,7-dihydro-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-4-one (66373-00-0) + pyrido[4,3-d]pyrimidin-4-one (16952-64-0)

Guidance literature:

With ammonia; In thionyl chloride;

upstream raw materials:

4-amino-3-ethoxycarbonylpyridine

formamidine

4-aminonicotinic acid

4-amino-1-ethylpyrazolo[3,4-b]-pyridin-5-carboxamide

Downstream raw materials:

(3-ethynyl-phenyl)-(pyrido[4,3-d]pyrimidin-4-yl)-amine hydrochloride

4-[2-[4-(t-butyl)phenyl]ethylamino]pyrido-[4,3-d]pyrimidine

4-Chlor-1,3,6-triaza-naphthalin

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