373638-25-6Relevant articles and documents
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues
Li, James J.,Wang, Haixia,Qu, Fucheng,Musial, Christa,Tino, Joseph A.,Robl, Jeffrey A.,Slusarchyk, Dorothy,Golla, Rajasree,Seethala, Ramakrishna,Dickinson, Kenneth,Giupponi, Leah,Grover, Gary,Sleph, Paul,Flynn, Neil,Murphy, Brian J.,Gordon, David,Kung, Melissa,Stoffel, Robert
, p. 1799 - 1802 (2007/10/03)
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.