ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

Base Information

Chemical Name:ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate
CAS No.:700376-29-0
Molecular Formula:C₂₀H₁₉NO₃
Molecular Weight:321.376
Hs Code.:

Synonyms:ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

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Chemical Property of ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

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Technology Process of ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

There total 3 articles about ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 74-88-4
methyl iodide

: 162097-81-6
ethyl 1,2-dihydro-4-(4-methylphenyl)-2-oxo-3-quinolinecarboxylate

: 700376-29-0
ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

Guidance literature:: ethyl 1,2-dihydro-4-(4-methylphenyl)-2-oxo-3-quinolinecarboxylate; With potassium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm031100t

Reference yield:

: 36192-63-9
2-amino-4'-methylbenzophenone

: 700376-29-0
ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 1 h / 20 °C

2.1: NaH / ethanol / 2 h / Heating

3.1: tetrabutylammonium bromide; KOH / tetrahydrofuran; dimethylformamide / 0.17 h / 20 °C

3.2: 89 percent / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

With potassium hydroxide; tetrabutylammomium bromide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm031100t

Reference yield:

: N-[2-(4-methyl-benzoyl)-phenyl]-malonamic acid ethyl ester

: 700376-29-0
ethyl 1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / ethanol / 2 h / Heating

2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran; dimethylformamide / 0.17 h / 20 °C

2.2: 89 percent / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

With potassium hydroxide; tetrabutylammomium bromide; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm031100t