6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1192310-22-7
Molecular Formula:C₁₅H₁₁ClN₄O₆S
Molecular Weight:410.795
Hs Code.:

Synonyms:6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 7 articles about 6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1192310-21-6
6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1192310-22-7
6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With sodium tungstate (VI) dihydrate; dihydrogen peroxide; In water; acetic acid; at 20 ℃; for 18h; Inert atmosphere of nitrogen;

Reference yield:

: 2444-36-2
2'-chloro-benzeneacetic acid

: 1192310-22-7
6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; sulfuric acid / water / 5 h / -10 - 0 °C

2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

With sulfuric acid; dihydrogen peroxide; nitric acid; potassium carbonate; 1,1'-carbonyldiimidazole; sodium tungstate (VI) dihydrate; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 37777-70-1
2-(2-chloro-5-nitrophenyl)acetic acid

: 1192310-22-7
6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide

3: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; potassium carbonate; 1,1'-carbonyldiimidazole; sodium tungstate (VI) dihydrate; In water; acetic acid; N,N-dimethyl-formamide;