6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1192310-23-8
Molecular Formula:C₁₈H₁₉ClN₆O₄
Molecular Weight:418.84
Hs Code.:

Synonyms:6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

There total 8 articles about 6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1192310-22-7
6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 108-00-9
N,N-dimethylethylenediamine

: 1192310-23-8
6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 100 ℃; for 0.25h; Irradiation with microwave;

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 1192310-23-8
6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: manganese(IV) oxide / chloroform / 20 - 40 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

5: hydrogenchloride / isopropyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation; Sealed vessel

With hydrogenchloride; manganese(IV) oxide; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; sodium tungstate (VI) dihydrate; In tetrahydrofuran; chloroform; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2444-36-2
2'-chloro-benzeneacetic acid

: 1192310-23-8
6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; sulfuric acid / water / 5 h / -10 - 0 °C

2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water; acetic acid / 18 h / 20 °C / Inert atmosphere

5: hydrogenchloride / isopropyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation; Sealed vessel

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; nitric acid; potassium carbonate; 1,1'-carbonyldiimidazole; sodium tungstate (VI) dihydrate; In water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;