bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

Base Information

Chemical Name:bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate
CAS No.:1268385-51-8
Molecular Formula:C₂₆H₃₂F₃N₃O₇
Molecular Weight:555.551
Hs Code.:

Synonyms:bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

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Chemical Property of bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

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Technology Process of bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

There total 8 articles about bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.3%

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1268385-50-7
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

: 1268385-51-8
bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

Guidance literature:: With lithium carbonate; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 7657-09-2
1,4-dibromo-2-(trifluoromethyl)benzene

: 1268385-51-8
bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tert-butyl methyl ether / 0 - 25 °C

1.2: 0 °C

1.3: 50 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide

2.2: 3 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

4.1: periodic acid / acetonitrile / 2 - 20 °C

4.2: 2 - 20 °C

5.1: methanol / 65 °C

6.1: lithium carbonate / N,N-dimethyl-formamide / 0 °C

With N-chloro-succinimide; n-butyllithium; lithium carbonate; periodic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; hexane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1268385-47-2
2-{3-[4-bromo-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268385-51-8
bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

2.1: periodic acid / acetonitrile / 2 - 20 °C

2.2: 2 - 20 °C

3.1: methanol / 65 °C

4.1: lithium carbonate / N,N-dimethyl-formamide / 0 °C

With lithium carbonate; periodic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;